genetics

George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.

By editing primary T cells with CRISPR, researchers begin to settle a long-standing debate about a common autoimmunity risk variant.

Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.

Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects.

Janet Mertz’s work with simian virus 40 DNA during her graduate years was pivotal for developing DNA recombination as we now know it.

In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.

Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.

A more complete understanding of nonrandom segregation will shed light on how speciation occurs.

Research on so-called selfish genetic loci is providing scientists with greater insight into the biology of chromosome segregation and inheritance.

SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 

Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.

Benedetta Artegiani and Delilah Hendriks are forming a joint laboratory group to understand disease mechanisms and treatments through organoid models.

Berg was awarded one-half of the Nobel Prize in Chemistry in 1980 for his work with recombinant DNA technology. 

Researchers found that copepod genomes adapt in distinct ways when simultaneously exposed to multiple environmental conditions.